Imaging basal ganglia function

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Imaging basal ganglia function.

In this review, the value of functional imaging for providing insight into the role of the basal ganglia in motor control is reviewed. Brain activation findings in normal subjects and Parkinson's disease patients are examined and evidence supporting the existence for functionally independent distributed basal ganglia-frontal loops is presented. It is argued that the basal ganglia probably act t...

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It has always been something of a mystery as to why different diseases of the basal ganglia may produce completely opposite effects on movement. Thus, defective dopaminergic inhibitory input into the striatum in Parkinson’s disease causes an akinetic-rigid syndrome, while destruction of the striatum in Huntington’s disease usually causes chorea. This theoretic paradox may be resolved by more de...

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Striatal Plasticity and Basal Ganglia Circuit Function

The dorsal striatum, which consists of the caudate and putamen, is the gateway to the basal ganglia. It receives convergent excitatory afferents from cortex and thalamus and forms the origin of the direct and indirect pathways, which are distinct basal ganglia circuits involved in motor control. It is also a major site of activity-dependent synaptic plasticity. Striatal plasticity alters the tr...

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Handbook of Basal Ganglia Structure and Function

It has been more than three decades now since B.S. Bunney, G.K. Aghajanian and their colleagues at Yale published the first electrophysiological studies of midbrain dopamine (DA) neurons in vivo ( Bunney et al., 1973a,b ). These extracellular single unit recordings revealed that DA neurons in the substantia nigra (SN) pars compacta (SNc) and ventral tegmental area (VTA) of chloral hydrate-anest...

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Functional magnetic resonance imaging evidence for disrupted basal ganglia function in schizophrenia.

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ژورنال

عنوان ژورنال: Journal of Anatomy

سال: 2000

ISSN: 0021-8782,1469-7580

DOI: 10.1046/j.1469-7580.2000.19640543.x